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Endogenous itaconate increases with IRG1 induction, and exogenous supplementation mitigates S-100-induced liver injury and transaminase elevation by dampening glycolysis, restraining dendritic cell maturation, and inhibiting autophagy through PI3K-AKT-mTOR, thereby improving the Th17/Treg balance and limiting CD4⁺ T-cell proliferation

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Additionally, BPC 157 is present in most tissues (Seiwerth et al., 2018), where it can bind reactive free radicals and inactivate them at crucial positions not reachable by other antioxidants (Sikiric et al., 1993